Which risk model is appropriate for calculating a patient's risk of having breast cancer due to a cancer susceptibility mutation?

Which risk model is appropriate for calculating a patient's risk of having breast cancer due to a cancer susceptibility mutation?

• A. Gail model
• B. Norwegian model
• C. Ford model
• D. Claus model

Answer: (C)

The Ford model is specifically designed to assess the risk of breast cancer in individuals who may carry mutations associated with hereditary breast and ovarian cancer syndromes, such as BRCA1 and BRCA2. This model takes into account family history, specifically the presence of breast cancer in first-degree and second-degree relatives, which is crucial for individuals with such mutations. The Gail model primarily evaluates risk based on personal and family history of breast cancer but does not focus on genetic factors specifically, making it less appropriate for those concerned about susceptibility mutations. The Norwegian model is tailored more towards the population in Norway and doesn't specifically address genetic risk factors. The Claus model also assesses familial risk but does not focus primarily on genetic mutations in the same way as the Ford model does. This focus on hereditary factors makes the Ford model the most suitable option for calculating risk related to cancer susceptibility mutations.

The Ford model is specifically designed to assess the risk of breast cancer in individuals who may carry mutations associated with hereditary breast and ovarian cancer syndromes, such as BRCA1 and BRCA2. This model takes into account family history, specifically the presence of breast cancer in first-degree and second-degree relatives, which is crucial for individuals with such mutations.

The Gail model primarily evaluates risk based on personal and family history of breast cancer but does not focus on genetic factors specifically, making it less appropriate for those concerned about susceptibility mutations. The Norwegian model is tailored more towards the population in Norway and doesn't specifically address genetic risk factors. The Claus model also assesses familial risk but does not focus primarily on genetic mutations in the same way as the Ford model does. This focus on hereditary factors makes the Ford model the most suitable option for calculating risk related to cancer susceptibility mutations.